Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: Comparison with pediatric pneumonia without H1N1 2009 infection
Identifieur interne : 000C87 ( Main/Exploration ); précédent : 000C86; suivant : 000C88Cytokine response in pediatric patients with pandemic influenza H1N1 2009 virus infection and pneumonia: Comparison with pediatric pneumonia without H1N1 2009 infection
Auteurs : Yeo Hyang Kim [Corée du Sud, Niger] ; Jung-Eun Kim [Corée du Sud] ; Myung Chul Hyun [Corée du Sud]Source :
- Pediatric Pulmonology [ 8755-6863 ] ; 2011-12.
English descriptors
- Teeft :
- Adaptive immunity, Allergic response, Assay, Autopsy case, Corticosteroid, Corticosteroid treatment, Cytokine, Cytokine levels, Cytokine response, Disease severity, High copy number, Higher levels, Higher serum levels, Important markers, Infection, Innate immunity, Intravenous immunoglobulin, Keimyung university school, Lymphocyte, Lymphocyte count, Mild pneumonia, Multiplex assay, Neuraminidase inhibitors, Oxygen saturation, Pandemic, Pediatric, Pediatric patients, Pediatric pulmonology, Pneumonia, Pneumonia patients, Present study, Pulmonology, Respiratory syncytial virus, Serum cytokine levels, Serum levels, Several cytokines, Severe disease, Severe pneumonia, Standard deviation, Study groups, University school, Virus infection, World health organization.
Abstract
Objectives: We investigated serum cytokine levels in pediatric patients with pandemic influenza H1N1 2009 virus (H1N1) infection‐pneumonia and in pediatric patients with pneumonia but without H1N1 infection, and examined correlations between cytokine levels and clinical/laboratory findings. Methods: Fifty‐seven cases of infection by H1N1 were confirmed by RT‐PCR and enrolled. Of these 57 cases, 26 had a severe H1N1 infection (group 1), and 31 had a mild H1N1 infection (group 2). Sera from 18 cases with pneumonia without H1N1 infection (group 3) were used as controls. The serum levels of 10 cytokines were determined by multiplex assay. Results: The serum levels of IFN‐α, IL‐6, and IP‐10 were significantly higher in H1N1 infected cases than in group 3, and levels of IL‐6 and IP‐10 were significantly higher in group 1 than in group 2. The level of IL‐10 was significantly higher in groups 1 and 3 than in group 2. However, levels of IFN‐γ and IL‐17 were not significantly different between the three groups. IL‐1β, IL‐4, and MIP‐1α were not detectable in most patients. IP‐10 and IL‐6 levels were found to show negative correlations with lymphocyte count and oxygen saturation. Conclusions: We found higher levels of cytokines (IFN‐α, IL‐6, IP‐10) of innate immunity than those of acquired immunity in pediatric H1N1 infection. Of the cytokines found to be increased in cases with H1N1 infection, IP‐10 and IL‐6 were found to be correlated with disease severity (lymphopenia and hypoxia). IP‐10 and IL‐6 may be important markers in pediatric H1N1 infection. Pediatr Pulmonol. 2011; 46: 1233–1239. © 2011 Wiley Periodicals, Inc.
Url:
DOI: 10.1002/ppul.21496
Affiliations:
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xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Keimyung University School of Medicine, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Niger</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Correspondence address: Department of Pediatrics, Keimyung University School of Medicine, 197 Dongsan‐dong, Jung‐gu, Daegu 700‐712</wicri:regionArea><wicri:noRegion>Daegu 700‐712</wicri:noRegion></affiliation></author><author><name sortKey="Kim, Jung Un" sort="Kim, Jung Un" uniqKey="Kim J" first="Jung-Eun" last="Kim">Jung-Eun Kim</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Molecular Medicine, Cell and Matrix Research Institute, Kyungpook National University School of Medicine, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author><author><name sortKey="Hyun, Myung Chul" sort="Hyun, Myung Chul" uniqKey="Hyun M" first="Myung Chul" last="Hyun">Myung Chul Hyun</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Pediatrics, Kyungpook National University School of Medicine, Daegu</wicri:regionArea><wicri:noRegion>Daegu</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatric Pulmonology</title><title level="j" type="alt">PEDIATRIC PULMONOLOGY</title><idno type="ISSN">8755-6863</idno><idno type="eISSN">1099-0496</idno><imprint><biblScope unit="vol">46</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1233">1233</biblScope><biblScope unit="page" to="1239">1239</biblScope><biblScope unit="page-count">7</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-12">2011-12</date></imprint><idno type="ISSN">8755-6863</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">8755-6863</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adaptive immunity</term><term>Allergic response</term><term>Assay</term><term>Autopsy case</term><term>Corticosteroid</term><term>Corticosteroid treatment</term><term>Cytokine</term><term>Cytokine levels</term><term>Cytokine response</term><term>Disease severity</term><term>High copy number</term><term>Higher levels</term><term>Higher serum levels</term><term>Important markers</term><term>Infection</term><term>Innate immunity</term><term>Intravenous immunoglobulin</term><term>Keimyung university school</term><term>Lymphocyte</term><term>Lymphocyte count</term><term>Mild pneumonia</term><term>Multiplex assay</term><term>Neuraminidase inhibitors</term><term>Oxygen saturation</term><term>Pandemic</term><term>Pediatric</term><term>Pediatric patients</term><term>Pediatric pulmonology</term><term>Pneumonia</term><term>Pneumonia patients</term><term>Present study</term><term>Pulmonology</term><term>Respiratory syncytial virus</term><term>Serum cytokine levels</term><term>Serum levels</term><term>Several cytokines</term><term>Severe disease</term><term>Severe pneumonia</term><term>Standard deviation</term><term>Study groups</term><term>University school</term><term>Virus infection</term><term>World health organization</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: We investigated serum cytokine levels in pediatric patients with pandemic influenza H1N1 2009 virus (H1N1) infection‐pneumonia and in pediatric patients with pneumonia but without H1N1 infection, and examined correlations between cytokine levels and clinical/laboratory findings. Methods: Fifty‐seven cases of infection by H1N1 were confirmed by RT‐PCR and enrolled. Of these 57 cases, 26 had a severe H1N1 infection (group 1), and 31 had a mild H1N1 infection (group 2). Sera from 18 cases with pneumonia without H1N1 infection (group 3) were used as controls. The serum levels of 10 cytokines were determined by multiplex assay. Results: The serum levels of IFN‐α, IL‐6, and IP‐10 were significantly higher in H1N1 infected cases than in group 3, and levels of IL‐6 and IP‐10 were significantly higher in group 1 than in group 2. The level of IL‐10 was significantly higher in groups 1 and 3 than in group 2. However, levels of IFN‐γ and IL‐17 were not significantly different between the three groups. IL‐1β, IL‐4, and MIP‐1α were not detectable in most patients. IP‐10 and IL‐6 levels were found to show negative correlations with lymphocyte count and oxygen saturation. Conclusions: We found higher levels of cytokines (IFN‐α, IL‐6, IP‐10) of innate immunity than those of acquired immunity in pediatric H1N1 infection. Of the cytokines found to be increased in cases with H1N1 infection, IP‐10 and IL‐6 were found to be correlated with disease severity (lymphopenia and hypoxia). IP‐10 and IL‐6 may be important markers in pediatric H1N1 infection. Pediatr Pulmonol. 2011; 46: 1233–1239. © 2011 Wiley Periodicals, Inc.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Niger</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Yeo Hyang" sort="Kim, Yeo Hyang" uniqKey="Kim Y" first="Yeo Hyang" last="Kim">Yeo Hyang Kim</name></noRegion><name sortKey="Hyun, Myung Chul" sort="Hyun, Myung Chul" uniqKey="Hyun M" first="Myung Chul" last="Hyun">Myung Chul Hyun</name><name sortKey="Kim, Jung Un" sort="Kim, Jung Un" uniqKey="Kim J" first="Jung-Eun" last="Kim">Jung-Eun Kim</name><name sortKey="Kim, Yeo Hyang" sort="Kim, Yeo Hyang" uniqKey="Kim Y" first="Yeo Hyang" last="Kim">Yeo Hyang Kim</name></country><country name="Niger"><noRegion><name sortKey="Kim, Yeo Hyang" sort="Kim, Yeo Hyang" uniqKey="Kim Y" first="Yeo Hyang" last="Kim">Yeo Hyang Kim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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